tcsc1394 (R) - (-) -Ibuprofen

(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

IC50 & Target: NF-κB^[2]

In Vitro: (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids^[1]. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC₅₀ of 121.8 μM, weaker than that of S(+)-ibuprofen (IC₅₀, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF^[2].