tcsc1349 ZM 306416

ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC₅₀s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC₅₀ of <10 nM.

IC50 & Target: IC50: 0.1 μM (KDR), 2 μM (Flt)^[1], <10 nM (EGFR)^[2]

In Vitro: ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC₅₀=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC₅₀>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC₅₀ value of 1.3±0.2 μM toward the ABL kinase^[2].