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BioChemicals
DMAT
tcsc1289
DMAT
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AVAILABLE SIZES
10mg
50mg
$
137.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
DMAT is a potent and specific
CK2
inhibitor with an
IC
50
value of 130 nM.
IC50 & Target: IC50: 130 nM (CK2)
[3]
In Vitro:
DMAT (1 μM-2.5 μM) DMAT is more efficient in killing antiestrogen resistant cells than parental antiestrogen sensitive MCF-7 cells. DMAT-induced cell death of antiestrogen resistant cells is mediated by caspases. DMAT inhibits CK2 activity but the inhibition is similar in the three cell lines, MCF-7, TAMR-1 and 182R-6
[1]
. DMAT has effects on H295R cell proliferation at concentrations of 10
-4
and 10
-5
mol/Las compared with the control. DMAT (100 μM) significantly increases apoptosis of H295R cells. DMAT (1 nM-1 μM) significantly decreases aldosterone release into supernatants of 72-h H295R cell cultures as compared with the control
[2]
. DMAT also inhibits PIM1 by a mechanism which is competitive with respect to ATP, and it is a powerful inhibitor of kinases other than CK2
[3]
.
In Vivo:
DMAT application in vivo reduces tumor growth in a xenotransplant model by interference with tumor cell proliferation. Biochemical parameters and histology following DMAT administration revealed no alterations in liver tissue
[4]
.
Information
CAS No
749234-11-5
Formula
C
9
H
7
Br
4
N
3
Clinical Information
clinicalinformation
Pathway
Stem Cell/Wnt
Cell Cycle/DNA Damage
Target
Casein Kinase
Casein Kinase
Specifications
Purity / Grade
>98%
Solubility
DMSO : 50 mg/mL (104.87 mM; Need ultrasonic)
Smiles
smiles
Misc Information
Alternative Names
Casein kinase II Inhibitor;CK2 Inhibitor
Observed Molecular Weight
476.79
related data
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