tcsc1289 DMAT

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Product Description

DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM.

IC50 & Target: IC50: 130 nM (CK2)[3]

In Vitro: DMAT (1 μM-2.5 μM) DMAT is more efficient in killing antiestrogen resistant cells than parental antiestrogen sensitive MCF-7 cells. DMAT-induced cell death of antiestrogen resistant cells is mediated by caspases. DMAT inhibits CK2 activity but the inhibition is similar in the three cell lines, MCF-7, TAMR-1 and 182R-6[1]. DMAT has effects on H295R cell proliferation at concentrations of 10-4 and 10-5mol/Las compared with the control. DMAT (100 μM) significantly increases apoptosis of H295R cells. DMAT (1 nM-1 μM) significantly decreases aldosterone release into supernatants of 72-h H295R cell cultures as compared with the control[2]. DMAT also inhibits PIM1 by a mechanism which is competitive with respect to ATP, and it is a powerful inhibitor of kinases other than CK2[3].

In Vivo: DMAT application in vivo reduces tumor growth in a xenotransplant model by interference with tumor cell proliferation. Biochemical parameters and histology following DMAT administration revealed no alterations in liver tissue[4].

Information

CAS No749234-11-5
FormulaC9H7Br4N3
Clinical Informationclinicalinformation
PathwayStem Cell/Wnt
Cell Cycle/DNA Damage
TargetCasein Kinase
Casein Kinase

Specifications

Purity / Grade>98%
SolubilityDMSO : 50 mg/mL (104.87 mM; Need ultrasonic)
Smilessmiles

Misc Information

Alternative NamesCasein kinase II Inhibitor;CK2 Inhibitor
Observed Molecular Weight476.79
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