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BioChemicals
AXL1717
tcsc1184
Picropodophyllin
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5mg
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100mg
$
120.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
Picropodophyllin (AXL1717) is a selective
insulin-like growth factor-1 receptor (IGF-1R)
inhibitor with an
IC
50
of 1 nM.
IC50 & Target: IC50: 1 nM (IGF-1R)
In Vitro:
Picropodophyllin (AXL1717) (0.5, 2.5, 10 μM) potently inhibits IGF-1-stimulated IGF-1R, Akt (Ser 473) and Erk1/2 phosphorylation in intact cells. Picropodophyllin (AXL1717) also inhibits cell growth, and induces apoptosis in cultured IGF-1R-positive tumor cells
[1]
. Picropodophyllin (AXL1717) synergistically sensitizes HMCL, primary human MM and murine 5T33MM cells to ABT-737 and ABT-199 via further decreasing cell viability and enhancing apoptosis
[3]
. Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells
[4]
.
In Vivo:
Picropodophyllin (AXL1717) (20 mg/kg/12 h, i.p.) causes complete tumor regression in SCID mice xenografted with human ES-1, BE, and PC3
[1]
. Picropodophyllin (AXL1717) shows a potent antitumor activity, increases survival in the 5T33MM mouse model
[2]
.
Information
CAS No
477-47-4
Formula
C
22
H
22
O
8
Clinical Information
clinicalinformation
Pathway
Protein Tyrosine Kinase/RTK
Target
IGF-1R
Specifications
Purity / Grade
>98%
Solubility
DMSO : 50 mg/mL (120.65 mM; Need ultrasonic)
Smiles
smiles
Misc Information
Alternative Names
AXL1717;Picropodophyllin;PPP
Observed Molecular Weight
414.41
related data
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