tcsc1184 Picropodophyllin

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Product Description

Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

IC50 & Target: IC50: 1 nM (IGF-1R)

In Vitro: Picropodophyllin (AXL1717) (0.5, 2.5, 10 μM) potently inhibits IGF-1-stimulated IGF-1R, Akt (Ser 473) and Erk1/2 phosphorylation in intact cells. Picropodophyllin (AXL1717) also inhibits cell growth, and induces apoptosis in cultured IGF-1R-positive tumor cells[1]. Picropodophyllin (AXL1717) synergistically sensitizes HMCL, primary human MM and murine 5T33MM cells to ABT-737 and ABT-199 via further decreasing cell viability and enhancing apoptosis[3]. Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells[4].

In Vivo: Picropodophyllin (AXL1717) (20 mg/kg/12 h, i.p.) causes complete tumor regression in SCID mice xenografted with human ES-1, BE, and PC3[1]. Picropodophyllin (AXL1717) shows a potent antitumor activity, increases survival in the 5T33MM mouse model[2].

Information

CAS No477-47-4
FormulaC22H22O8
Clinical Informationclinicalinformation
PathwayProtein Tyrosine Kinase/RTK
TargetIGF-1R

Specifications

Purity / Grade>98%
SolubilityDMSO : 50 mg/mL (120.65 mM; Need ultrasonic)
Smilessmiles

Misc Information

Alternative NamesAXL1717;Picropodophyllin;PPP
Observed Molecular Weight414.41
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