tcsc1170 DL-threo-2-methylisocitrate

DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1).

IC50 value:

Target:

The Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 μM using Michaelis-Menten non-linear least squares fit, with a kcat of 5.24 s-1. The Km for DL-threo-2-methylisocitrate (MICA) was approximately fourfold higher at 718 μM with a kcat of 1.25 s-1.