tcsc1099 TAK1 / MAP4K2 inhibitor 1

TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC₅₀s of 41.1 nM and 18.2 nM, respectively.

In Vivo: TAK1/MAP4K2 inhibitor 1 has moderate terminal elimination half-life (t_1/2=2.94 h for mice (1 mg/kg, iv))^[1].