tcsc1061 Idarubicin (hydrochloride)

Idarubicin hydrochloride is an anthracycline antibiotic in the treatment of leukaemia and a DNA topoisomerase II inhibitor.

IC50 & Target: DNA topoisomerase II^[1]

In Vitro: The IC₅₀ of idarubicin is 3.3±0.4 ng/mL on MCF-7 monolayers and 7.9±1.1 ng/mL in multicellular spheroids^[1]. Idarubicin has shown a greater cytotoxicity than daunorubicin or doxorubicin in various in vitro systems. This has been attributed to a better ability of idarubicin to induce the formation of topoisomerase II -mediated DNA breaks^[2].Idarubicin is about 57.5-fold and 25-fold more active than doxorubicin and epirubicin, respectively^[3]. Idarubicin produces a concentration-dependent reduction in cell growth, with an IC₅₀ value of approximately 0.01 μM. Idarubicin produced a concentration-dependent inhibition of DNA synthesis^[4].