tcsc1028 (S) -Timolol (Maleate)

(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).

IC50 Value: 1.97 nM(Ki for β1); 2.0 nM(Ki for β2)

Target: β-adrenergic receptor

(S)-Timolol, 50% bioavailability following oral administration. Does not cross the blood brain barrier. Timolol maleate does appear to have some local anesthetic properties in human cornea after chronic use by susceptible individuals.