tcsc0894 BIX-01294

BIX-01294 is an inhibitor of G9a Histone Methyltransferase with IC₅₀ of 1.9 μM.

IC50 & Target: IC50: 1.9 μM (G9a Histone Methyltransferase)



In Vitro: BIX-01294 (4.1 μM) treatment of G9anull ES cells results in a further reduction in H3K9me2 levels. BIX-01294 reduces H3K9me2 at several G9a target genes^[1]. BIX-01294 (5 µM) reduces levels of global H3K9 methylation in pronuclear- and 2-cell-stage embryos. Embryos transiently exposed to BIX-01294 have a reduced ability to establish pregnancy^[2]. BIX-01294 (1 µg/mL) causes reduction in the BrdU incorporation of fetal PASMCs. BIX-01294 treatment decreases the PASMCs migration induced by PDGF^[3].