tcsc0800 Calcifediol

Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent K_i of 3.9 μM, suppresses PTH secretion and mRNA (ED₅₀=2 nM).

In Vitro: Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival^[1].