tcsc0794 MPEP

MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors.

IC50 value: 36 nM

Target: mGluR5

Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.