tcsc0775 Chroman 1

Chroman 1 is a highly potent ROCK2 inhibitor, with an IC₅₀ of < 1 nM.

IC50 & Target: IC50: < 1 nM (ROCK2)^[1]

In Vitro: Chroman 1 is a highly potent ROCK2 inhibitor, with an IC₅₀ of < 1 nM. Chroman 1 also shows inhibitory activities against MRCK, with an IC₅₀ of 150 nM, but has no effect on PKA (IC₅₀, > 20000 nM) or AKT1 (IC₅₀, > 20000 nM)^[1].