tcsc0463 Glucose-conjugated MGMT inhibitor

Glucose-conjugated MGMT inhibitor is a potent O⁶-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC₅₀s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells.

IC50 & Target: IC50: 32 nM (MGMT, cell extracts) and 10 nM (MGMT, HeLa S3 cells)^[1]

In Vitro: Glucose-conjugated MGMT inhibitor (O6BTG-octylglucoside) is a potent and non-toxic MGMT inhibitor, with IC₅₀s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells^[1].