tcsc0404 CMK

CMK is a RSK2 kinase inhibitor, used for cancer treatment.

In Vitro: CMK inhibits the growth of Cdc5 (L158G) with IC₅₀ of 36 nM, greater than 30 μM for wild type Cdc5. CMK exhibits a concentration-dependent first cell cycle mitotic arrest in the cdc5-as1 strain with an IC₅₀ of 1.1 μM. CMK inhibition of Cdc5 (L158G) leads to a first cell cycle anaphase arrest and delay in anaphase spindle migration^[1].