tcsc0393 Ercalcidiol

Ercalcidiol is a metabolite of vitamin D₂, is regarded as an indicator of vitamin D nutritional status.

IC50 & Target: Vitamin D₂^[1]

In Vitro: Differentiation between Ercalcidiol (25(OH)D₂) and 25(OH)D₃ is important for monitoring vitamin D therapy, as vitamin D₂ is the predominant prescription form. The half-life of Ercalcidiol is shorter than that of 25(OH)D₃ and it binds less well to the vitamin D binding protein, making it less potent and, therefore, required to be administered at much higher doses than vitamin D₃. Some currently used assays have a diminished capacity to detect Ercalcidiol, which can lead to dangerous overdosing when attempting to monitor therapy with vitamin D₂^[2].