tcsc0300 T863

T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.

IC50 value:

Target: DGAT1

T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.