tcsc0271 A-867744

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Product Description

A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs.

IC50 value: ~ 1 uM

Target: α7 nAChR

Target:

Information

CAS No1000279-69-5
FormulaC20H19ClN2O3S
Clinical Informationclinicalinformation
PathwayNeuronal Signaling
Membrane Transporter/Ion Channel
Autophagy
TargetnAChR
nAChR
Autophagy

Specifications

Purity / Grade>98%
SolubilityDMSO : ≥ 100 mg/mL (248.21 mM)
Smilessmiles

Misc Information

Observed Molecular Weight402.89
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