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BioChemicals
Alisertib
tcsc0106
Alisertib
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$
103.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
Alisertib (MLN 8237) is a selective
Aurora A
inhibitor with an
IC
50
of 1.2 nM.
IC50 & Target: IC50: 1.2 nM (Aurora A)
[3]
In Vitro:
Alisertib leads the MM cells to mitotic spindle abnormalities, mitotic accumulation, as well as inhibition of cell proliferation through apoptosis and senescence. Alisertib up-regulates p53 and tumor suppressor genes p21 and p27
[1]
. The decreased activity of MLN8054/Alisertib for the T217D/W277E Aurora A/TPX2 complex may reflect the increased affinity for ATP induced by cofactor binding to Aurora A
[2]
. Alisertib inhibits cell proliferation with IC
50
values ranging from 15 to 469 nM in different tumer cell lines
[3]
.
In Vivo:
Alisertib (Alisertib, 30 mg/kg, p.o.) significantly reduces tumor burden and increases overall survival in xenograft-murine model of human-MM
[1]
. Alisertib (20, 30 mg/kg, p.o.) causes tumor growth inhibition in solid tumor xenograft models and regressions in in vivo models of lymphoma, and reduces FLT uptake in HCT-116 xenograft tumors
[3]
.
Information
CAS No
1028486-01-2
Formula
C
27
H
20
ClFN
4
O
4
Clinical Information
clinicalinformation
Pathway
Cell Cycle/DNA Damage
Epigenetics
Autophagy
Target
Aurora Kinase
Aurora Kinase
Autophagy
Specifications
Purity / Grade
>98%
Solubility
DMSO : 9.33 mg/mL (17.98 mM; Need ultrasonic and warming)
Smiles
smiles
Misc Information
Alternative Names
MLN 8237
Observed Molecular Weight
518.92
related data
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