tcsc0072 SB 239063

SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580.

IC50 value: 44 nM ( p38α)

Target: p38 MAPK

SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.