tcsc0042359 Protein degrader 1 (TFA)

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Product Description

Protein degrader 1 TFA is a small molecule ligand for VHL, an E3 ligase which has been targeted in numerous PROTACs.

IC50 & Target: E3 ligase VHL[1]

In Vitro: Synthesis of HaloPROTACs contains Protein degrader 1 (Degradation Inducing Moiety A). Protein degrader 1 (Degradation Inducing Moiety A) is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. HaloPROTACs containing Protein degrader 1 (Degradation Inducing Moiety A) lead to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used[1].

Information

CAS No1631137-51-3
FormulaC24H31F3N4O5S
Clinical Informationclinicalinformation
PathwayPROTAC
TargetLigand for E3 Ligase

Specifications

Purity / Grade>98%
Solubility10 mM in DMSO
Smilessmiles

Misc Information

Observed Molecular Weight544.59
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