tcsc0040672 1-Ethynylnaphthalene

1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.

IC50 & Target: P450 1B1^[1]

In Vitro: 1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E₂) by ~30% and 4-hydroxylation of E₂ by up to 80%^[1].