tcsc0040308 E-7386

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Data sheet

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Product Description

E-7386 is an orally active CBP/beta-catenin modulator.

IC50 & Target: CBP/beta-catenin[1]

In Vivo: E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group[1].

Information

CAS No1799824-08-0
FormulaC39H48FN9O4
Clinical Informationclinicalinformation
PathwayEpigenetics
TargetEpigenetic Reader Domain

Specifications

Purity / Grade>98%
Solubility10 mM in DMSO
Smilessmiles

Misc Information

Observed Molecular Weight725.85
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