tcsc0039394 PhiKan 083 hydrochloride

PhiKan 083 hydrochloride is a carbazole derivative, which can stabilize Y220C (a p53 mutant), with a K_d of 167 μM measured by NMR, used for cancer research.

IC50 & Target: Kd: 167 μM (T-p53C-Y220C)^[1]

In Vitro: PhiKan 083 hydrochloride is a stabilizer of Y220C (a p53 mutant), with a K_d of 167 μM measured by NMR. Analytical ultracentrifugation gives a K_d of 170 μM for PhiKan083, at 10°C. Isothermal titration of PhiKan083 with T-p53C-Y220C gives 1:1 stoichiometry and a K_d of 125 ± 10 μM^[1]. PhiKan083 can binds with the cavity on the surface of Y220C-mutated p53^[2].