tcsc0035114 HDAC8-IN-1

HDAC8-IN-1 is a HDAC8 inhibitor with an IC₅₀ of 27.2 nM.

IC50 & Target: IC50: 27.2 nM (HDAC8)

In Vitro: HDAC8-IN-1 is a HDAC8 inhibitor with an IC₅₀ of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells^[1].