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BioChemicals
AZD5904
tcsc0035112
AZD5904
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AVAILABLE SIZES
5mg
10mg
25mg
50mg
100mg
$
200.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Western blot (WB)
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Immunofluorescence (IF)
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RNA Binding Protein Immunoprecipitation (RIP)
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Product Description
AZD5904 is a potent and irreversible inhibitor of human
Myeloperoxidase
(
MPO
) with an
IC
50
of 140 nM and has similar potency in mouse and rat.
IC50 & Target: IC50: 140 nM (human MPO)
[1]
In Vitro:
AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC
50
of 140 nM and has similar potency in mouse and rat. It is 10 to 19-fold selective compare to the closely related lactoperoxidase and thyroid peroxidase; >70-fold to a broad panel of other enzymes, ion channels, and receptors. In isolated human neutrophils, 1 µM AZD5904 inhibits PMA stimulated HOCl by >90%
[1]
.
Information
CAS No
618913-30-7
Formula
C
10
H
12
N
4
O
2
S
Clinical Information
clinicalinformation
Pathway
Metabolic Enzyme/Protease
Target
Glutathione Peroxidase
Specifications
Purity / Grade
>98%
Solubility
DMSO : 125 mg/mL (495.46 mM; Need ultrasonic and warming)
Smiles
smiles
Misc Information
Observed Molecular Weight
252.29
related data
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