tcsc0035112 AZD5904

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Product Description

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.

IC50 & Target: IC50: 140 nM (human MPO)[1]

In Vitro: AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat. It is 10 to 19-fold selective compare to the closely related lactoperoxidase and thyroid peroxidase; >70-fold to a broad panel of other enzymes, ion channels, and receptors. In isolated human neutrophils, 1 µM AZD5904 inhibits PMA stimulated HOCl by >90%[1].

Information

CAS No618913-30-7
FormulaC10H12N4O2S
Clinical Informationclinicalinformation
PathwayMetabolic Enzyme/Protease
TargetGlutathione Peroxidase

Specifications

Purity / Grade>98%
SolubilityDMSO : 125 mg/mL (495.46 mM; Need ultrasonic and warming)
Smilessmiles

Misc Information

Observed Molecular Weight252.29
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