tcsc0035112 AZD5904

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC₅₀ of 140 nM and has similar potency in mouse and rat.

IC50 & Target: IC50: 140 nM (human MPO)^[1]

In Vitro: AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC₅₀ of 140 nM and has similar potency in mouse and rat. It is 10 to 19-fold selective compare to the closely related lactoperoxidase and thyroid peroxidase; >70-fold to a broad panel of other enzymes, ion channels, and receptors. In isolated human neutrophils, 1 µM AZD5904 inhibits PMA stimulated HOCl by >90%^[1].