tcsc0028638 UVI 3003

UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC₅₀s of 0.22 and 0.24 μM, respectively.

IC50 & Target: IC50: 0.22 μM (Xenopus RXRα, in Cos7 cells), 0.24 μM (Human RXRα, in Cos7 cells)^[1]

In Vitro: UVI3003 inhibits the activity of xenopus and human RXRα, with IC₅₀s of 0.22 and 0.24 μM, respectively. UVI3003 fully activates xPPARγ with an EC₅₀ of 12.6 μM, and is almost completely inactive on hPPARγ and mPPARγ^[1]. UVI 3003 (10 μM) does not change the proliferation rate of extraocular muscles (EOM)-derived or LEG-derived EECD34 cells. UVI 3003 causes a 65.4% difference in EECD34 cell fusion and desmin expression^[2].