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BioChemicals
PDD 00017273
tcsc0028457
PDD 00017273
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AVAILABLE SIZES
5mg
10mg
25mg
$
271.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (
PARG
), with an
IC
50
of 26 nM, and a
K
D
of 1.45 nM.
IC50 & Target: IC50: 26 nM (PARG)
[1]
KD: 1.45 nM (PARG)
[1]
In Vitro:
PDD 00017273 is a potent inhibitor of PARG, with an IC
50
of 26 nM, and a K
D
of 1.45 nM. PDD 00017273 (10 μM) does not inhibit five common Cytochrome P450 enzymes. PDD 00017273 (30 μM) modestly increasess phosphorylated H2AX (γH2AX) intensity, PDD 00017273 also decreases in NAD/H through PARG inhibition after DNA damage. PDD 00017273 suppresses the ZR-75-1 cells carring BRCA1 and BRCA2 wild type, and exhibits less potent activities against MDA-MB-436 cells carry the 5396 + 1G>A mutation in BRCA1
[1]
. PDD 00017273 (0.3 μM) inhibits degradation of PAR polymers in MCF7 cells. PDD 00017273 (0.3 μM) also reduces the viability of BRCA1, BRCA2, PALB2, FAM175A, and BARD1 depleted cells. PDD 00017273 stalls replication forks and induces DNA damage that requires homologous recombination (HR) for repair
[2]
.
Information
CAS No
1945950-21-9
Formula
C
23
H
26
N
6
O
4
S
2
Clinical Information
clinicalinformation
Pathway
Others
Target
Others
Specifications
Purity / Grade
>98%
Solubility
10 mM in DMSO
Smiles
smiles
Misc Information
Observed Molecular Weight
514.62
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