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BioChemicals
JNJ0966
tcsc0027987
JNJ0966
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$
326.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
JNJ0966 is a highly selective
MMP-9 zymogen
inhibitor with an
IC
50
of 440 nM.
IC50 & Target: IC50: 440 nM (MMP-9 zymogen)
[1]
In Vitro:
JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC
50
of 440 nM. The activations of proMMP-1, proMMP-2, and proMMP-3 are not significantly different in the presence or absence of 10 μM JNJ0966, whereas proMMP-9 activation by trypsin is significantly attenuated by JNJ0966. The addition of JNJ0966 to the reaction results in a significant reduction in fully processed MMP-9 and an apparent accumulation of the intermediate species
[1]
.
In Vivo:
The exposures of JNJ0966 are dose-dependent, with plasma and brain concentrations for the 10-mg/kg dose of 77.5±31.1 ng/mL (215 nM) and 481.6±162.5 ng/g (~1336 nM), respectively, whereas the 30-mg/kg dose achieves 293.6±118.4 ng/mL (815 nM) in plasma and 1394.0±649.1 ng/g (~3867 nM) in brain. JNJ0966 is preferentially partitioned in brain, with brain/plasma ratios of 6.2 for the 10-mg/kg dose and 4.7 for the 30-mg/kg dose
[1]
.
Information
CAS No
315705-75-0
Formula
C
16
H
16
N
4
O
2
S
2
Clinical Information
clinicalinformation
Pathway
Metabolic Enzyme/Protease
Target
MMP
Specifications
Purity / Grade
>98%
Solubility
DMSO : 160 mg/mL (443.89 mM; Need ultrasonic and warming)
Smiles
smiles
Misc Information
Observed Molecular Weight
360.45
related data
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