tcsc0022886 WM-8014

WM-8014 is an inhibitor of MOZ, a member of histone acetyltransferases, with an IC₅₀ of 55 nM.

IC50 & Target: IC50: 55 nM (MOZ)^[1]

In Vitro: WM-8014 (Compound 36) is an inhibitor of MOZ, with an IC₅₀ of 55 nM. WM-8014 causes cell senescence and suppresses the proliferation with IC₅₀s of 1.6 μM and 551 nM, respectively. WM-8014 also reduces mRNA coding for the MOZ gene Cdc6 by 65.1%^[1].