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BioChemicals
L-Kynurenine
tcsc0022016
L-Kynurenine
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AVAILABLE SIZES
50mg
$
71.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an
aryl hydrocarbon receptor
agonist.
IC50 & Target: Target: Aryl Hydrocarbon Receptor
[1]
In Vitro:
Kynurenine and its further breakdown products carry out diverse biological functions, including dilating blood vessels during inflammation and regulating the immune response. Some cancers increase kynurenine production, which increases tumor growth. L-kynurenine (Kyn) is an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype. Kynurenine activates AHR signaling at physiological concentrations in H1L7.5c3 cells and acts as an AHR agonist after a 24-hr exposure by inducing the AHR-regulated luciferase gene in H1L7.5c3 mouse hepatocyte cells
[1]
.
In Vivo:
Kynurenine dilates arteries from rats as well as humans via Kv7 channels in the vascular smooth muscle. In rats, this tryptophan metabolite causes hypotension, which is partly counteracted by Kv7 channel inhibition
[2]
. L-kynurenine administered 1 h before the hypoxia-ischemia shows a dose-dependent significant neuroprotective effect, with complete protection at a dose of 300 mg/kg. The induction of c-fos immunoreactivity in cerebral cortex is also blocked by this dose of L-kynurenine
[3]
.
Information
CAS No
2922-83-0
Formula
C
10
H
12
N
2
O
3
Clinical Information
clinicalinformation
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Target
Aryl Hydrocarbon Receptor
Endogenous Metabolite
Specifications
Purity / Grade
>98%
Solubility
DMSO : 50 mg/mL (240.14 mM; Need ultrasonic)
Smiles
smiles
Misc Information
Observed Molecular Weight
208.21
related data
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