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BioChemicals
D-AP5
tcsc0020421
D-AP5
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AVAILABLE SIZES
5mg
10mg
$
114.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
D-AP5 is a
NMDA
receptor antagonist.
IC50 & Target: NMDA
[1]
In Vivo:
D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP)
in vivo
. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented
[1]
. D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze
[2]
.
D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze[3].
Information
CAS No
79055-68-8
Formula
C
5
H
12
NO
5
P
Clinical Information
clinicalinformation
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
iGluR
iGluR
Specifications
Purity / Grade
>98%
Solubility
10 mM in DMSO
H2O : 50 mg/mL (ultrasonic);Ethanol : 2 mg/mL (ultrasonic)
Smiles
smiles
Misc Information
Alternative Names
D-APV;D-2-Amino-5-phosphonovaleric acid
Observed Molecular Weight
197.13
References
[1]. R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75(1):65-75.
[2]. Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.
[3]. Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.
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