tcsc0018472 MCHr1 antagonist 2

MCHr1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC₅₀ of 65 nM; MCHr1 antagonist 2 also inhibits hERG, with an IC₅₀ of 4.0 nM in IMR-32 cells.

IC50 & Target: IC50: 65 nM (melanin concentrating hormone receptor 1), 4.0 nM (hERG in IMR-32 cells)^[1]

In Vitro: MCHr1 antagonist 2 (Compound 30) is an antagonist of melanin concentrating hormone receptor 1, with an IC₅₀ of 65 nM. MCHr1 antagonist 2 has inhibitory effects on Ca²⁺ flux, and hERG, with IC₅₀s of 196 ± 30 nM and 4.0 ± 0.8 nM, respectively, in IMR-32 cells^[1].