tcsc0018458 PNU-176798

PNU-176798 is an antimicrobial agent, targeting protein synthesis in a wide spectrum of gram-positive and anaerobic bacteria.

IC50 & Target: Bacterial^[1]

In Vitro: PNU-176798 is an antimicrobial agent, with a minimum inhibitory concentration (MIC) of 1.4 μM for E. coli. PNU-176798 inhibits fMet-tRNA binding to the 70S ribosomes, with an IC₅₀ of 32 μM. PNU-176798 also blocks translation, 70S initiation with IC₅₀s of 0.53, and 32 μM, respectively. PNU-176798 inhibits peptidyl transferase (IC₅₀, 40 μM), and the inhibition is more pronounced in the presence of elongation factor P (EF-P). PNU-176798 markedly inhibits the EF-G-mediated translocation of fMet-tRNA (IC₅₀, 8 μM)^[1].