tcsc0018449 MK-447

MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH₂, and other prostaglandins.

IC50 & Target: Prostaglandin Receptor^[1][2]

In Vitro: MK-447 is a free radical scavenger, reduces the accumulation of the endoperoxide, PGG₂ and also enhances the formation of the endoperoxide, PGH₂, and other prostaglandins^[1]. MK-447 (100 μM) increases the amounts of prostaglandin I2 (PGI2). MK-447 also accelerates endogenous PGI2 generation in the isolated rat aorta^[2].

In Vivo: MK-447 (20 and 50 mg/kg, p.o.) blocks gastric acid secretion in the 4 hour pylorus ligated rats, but shows no effect on gastric secretion of pepsin. MK-447 (5, 10, 20 and 40 mg/kg, p.o.) dose-dependently decreases acid output in dogs^[1].