tcsc0018406 Tiodazosin

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Product Description

Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist.

IC50 & Target: alpha adrenergic receptor[1]

In Vitro: Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. In the mesenteric artery, Tiodazosin produces a parallel shift to the right in the concentration response curves to norepinephrine. A Schild plot constructed from two concentrations of Tiodazosin results in a pA2 value of 8.66 and a slope equal to -0.99. Tiodazosin inhibits contraction to norepinephrine in the portal vein and the inhibition results in a nonparallel inhibition of the norepinephrine concentration-response curve with a marked depression of maximal norepinephrine response[1].

Information

CAS No66969-81-1
FormulaC18H21N7O4S
Clinical Informationclinicalinformation
PathwayGPCR/G Protein
TargetAdrenergic Receptor

Specifications

Purity / Grade>98%
Solubility10 mM in DMSO
Smilessmiles

Misc Information

Alternative NamesBL-5111
Observed Molecular Weight431.47
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