tcsc0015542 Esonarimod

Esonarimod is an antirheumatic drug.

In Vitro: Esonarimod (KE-298) (10 to 300 μg/mL) suppresses the production of NO by RAW264.7 cells in a dose dependent manner. The IC₅₀ of Esonarimod is 117.5 μg/mL. Esonarimod does not affect cellular viability at these tested doses. Esonarimod has no direct effect on NOS activity in cell-free extracts of RAW264.7 cells^[1].

In Vivo: After repeated oral administration of Esonarimod (¹⁴C-KE-298), the radioactivity decreases rapidly and no tendency towards accumulation is found^[2].