tcsc0012738 IWP-4

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Product Description

IWP-4 is a small molecule Wnt inhibitor with an IC50 of 25 nM.

IC50 & Target: IC50: 25 nM (Wnt)[1]

In Vitro: IWP-4 is a small molecule Wnt inhibitor with an IC50 of 25 nM. IWP-4 induces the expression of cardiac markers, including cardiac troponin I (CTNI) and cardiac myosin heavy chain bright cells (MYHhi +). IWP-4 also results in the appearance of beating foci (0.44±0.10 SEM beats per second), which is absent in all cultures not receiving IWP-4. Further, flow cytometric analysis shows that there are significantly more MYHlo + cells in IWP-4 treated cultures (P<0.0002) compare with untreated cultures at day 16, being 17.0±1.3 SD% and 5.4±1.4 SD%, respectively. Quantification of NKX2-5 protein expression shows that 63% (481/817) of IWP-4 treated cells display nuclear NKX2-5 expression[1]. Mesenchymal precursor cells (MPCs) treated with IWP-4 show no significant changes in the expression of AXIN2, CTNNB1 and GSK3B as compare to osteogenic medium alone on day 7, but MPCs treated with IWP-4 express elevates levels of DKK1 and GSK3β on day 21. IWP-4 also causes a significant down regulation of SPARC and COL1A1[2].



Information

CAS No686772-17-8
FormulaC23H20N4O3S3
Clinical Informationclinicalinformation
PathwayStem Cell/Wnt
TargetWnt

Specifications

Purity / Grade>98%
SolubilityDMSO : 5 mg/mL (10.07 mM; Need ultrasonic and warming)
Smilessmiles

Misc Information

Observed Molecular Weight496.62
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