tcsc0011636 LEQ506

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Product Description

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.

IC50 & Target: IC50: 2 nM (human smo), 4 nM (mouse smo)[1]

In Vitro: LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. LEQ506 inhibits Hedgehog (Hh) signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2[1]. LEQ506 is an efficacious compound by consistently decreasing Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and of 60 to 70% for Ptch1[2].

Information

CAS No1204975-42-7
FormulaC25H32N6O
Clinical Informationclinicalinformation
PathwayStem Cell/Wnt
TargetSmo

Specifications

Purity / Grade>98%
SolubilityDMSO : ≥ 100 mg/mL (231.18 mM)
Smilessmiles

Misc Information

Alternative NamesNVP-LEQ506
Observed Molecular Weight432.56
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