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BioChemicals
Gentiopicroside
tcsc0009015
Gentiopicroside
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$
100.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
Gentiopicroside, a naturally occurring iridoid glycoside, inhibits
P450
activity, with an IC
50
and a K
i
of 61 µM and 22.8 µM for CYP2A6; Gentiopicroside has antianti-inflammatoryand antioxidative effects.
IC50 & Target: IC50: 61 µM (CYP2A6)
[1]
Ki: 22.8 µM (CYP2A6)
[1]
In Vitro:
Gentiopicroside inhibits P450 activity, with an IC
50
and a K
i
of 61 µM and 8.12 µM for CYP2A6, also slightly inhibits CYP2E1 activity with an IC
50
of 1.6 mM, but shows no inhibition on CYP1A2 and CYP3A4
[1]
. Gentiopicroside (12.5, 25 and 50 μM) inhibits RANKL-induced osteoclast formation from mouse bone marrow macrophages (BMMs) in a dose-dependent manner, blocks the expression of osteoclast-related proteins, prevents receptor activator of nuclear factor-κB ligand (RANKL)-triggered JNK and NF-κB activation. Gentiopicroside (50 μM) also inhibits RANKL-induced bone resorption
[3]
.
In Vivo:
Gentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice
[2]
.
Information
CAS No
20831-76-9
Formula
C
16
H
20
O
9
Clinical Information
clinicalinformation
Pathway
Metabolic Enzyme/Protease
Target
Cytochrome P450
Specifications
Purity / Grade
>98%
Solubility
DMSO : ≥ 150 mg/mL (420.97 mM)
Smiles
smiles
Misc Information
Alternative Names
Gentiopicrin
Observed Molecular Weight
356.32
related data
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