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BioChemicals
ZM-447439
tcsc0009
ZM-447439
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AVAILABLE SIZES
5mg
10mg
50mg
$
129.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
ZM-447439 is an
aurora
kinase inhibitor with
IC
50
s of 110 and 130 nM for aurora A and B, respectively.
IC50 & Target: IC50: 110 nM (Aurora A), 130 nM (Aurora B)
[1]
In Vitro:
Cells treated with ZM-447439 progress through interphase, enter mitosis normally, and assemble bipolar spindles. However, chromosome alignment, segregation, and cytokinesis all fail. ZM-447439 inhibits cell division and inhibit mitotic phosphorylation of histone H3. ZM-447439 prevents chromosome alignment and segregation. ZM-447439 compromises spindle checkpoint function. ZM-447439 inhibits kinetochore localization of BubR1, Mad2, and Cenp-E
[1]
. Inhibition of Aurora kinase by ZM-447439 reduces histone H3 phosphorylation at Ser10 in Hep2 carcinoma cells. Multipolar spindles are induced in these ZM-treated G2/M-arrested cells with accumulation of 4N/8N DNA, similar to cells with genetically suppressed Aurora-B. ZM-447439 treatment induces cell apoptosis. ZM-447439 inhibition of Aurora kinase is potently in association with decrease of Akt phosphorylation at Ser473 and its substrates GSK3α/β phosphorylation at Ser21 and Ser9
[2]
.
Information
CAS No
331771-20-1
Formula
C
29
H
31
N
5
O
4
Clinical Information
clinicalinformation
Pathway
Cell Cycle/DNA Damage
Epigenetics
Target
Aurora Kinase
Aurora Kinase
Specifications
Purity / Grade
>98%
Solubility
DMSO : ≥ 100 mg/mL (194.71 mM)
Smiles
smiles
Misc Information
Observed Molecular Weight
513.59
related data
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