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BioChemicals
(+) -Catechin hydrate
tcsc0008908
(+) -Catechin hydrate
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AVAILABLE SIZES
100mg
$
71.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
(+)-Catechin hydrate inhibits cyclooxygenase-1 (
COX-1
) with an
IC
50
of 1.4 μM.
IC50 & Target: IC50: 1.4 uM (COX-1)
[1]
In Vitro:
(+)-Catechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC
50
of 1.4 μM
[1]
. A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC
50
of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis. The expression levels of
Caspase-3
,
-8
, and
-9
and
p53
in MCF-7 cells treated with 150 μg/mL (+)-Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells
[2]
.
In Vivo:
Animals treated with (+)-Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively)
[3]
.
Information
CAS No
225937-10-0
Formula
C
15
H
14
O
6
.xH
2
O
Clinical Information
clinicalinformation
Pathway
Immunology/Inflammation
Target
COX
Specifications
Purity / Grade
>98%
Solubility
DMSO : 150 mg/mL (Need ultrasonic and warming)
Smiles
smiles
Misc Information
Observed Molecular Weight
1000
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