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BioChemicals
Monensin sodium salt
tcsc0007881
Monensin sodium salt
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AVAILABLE SIZES
100mg
$
71.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
Monensin sodium salt is an antibiotic secreted by the bacteria
Streptomyces cinnamonensis
.
IC50 & Target: bacterial
[1]
In Vitro:
Monensin sodium salt is an antibiotic secreted by the bacteria
Streptomyces cinnamonensis
. Untreated cells display 2.5% apoptosis; 48 hours treatment with 1 μM Monensin sodium salt shows 4.5% apoptosis whereas 5 μM Monensin sodium salt for 48 hours induces a greater apoptotic response (16.4%). Pretreatment with either 1 or 5 μM Monensin sodium salt for 24 hours followed by 10 μM erlotinib treatment for another 24 hours results in a marked increases in apoptotic events (14.6% and 38.7%, respectively) when compare with either Monensin sodium salt or erlotinib treatments alone. Combination of 5 μM Monensin sodium salt with 10 μM erlotinib shows the highest percentage of apoptosis (38.7%)
[1]
.
In Vivo:
Although the numbers of tumors do not change substantially, a significant (P=0.0144) reduction in the average size of lesions is observed in Monensin sodium salt-treated Apc
+/Min
mice when compare with control animals (mean 0.199 mm
2
vs. 0.299 mm
2
). The total tumor area estimated in one animal is decreased in individuals receiving Monensin sodium salt (mean 10.16 mm
2
vs. 16.46 mm
2
; P=0.0125). Monensin sodium salt treatment increases the numbers of apoptotic cells and cells expressing the p21 cell-cycle inhibitor at the surface area of the neoplastic outgrowths. No changes in the cell proliferation, differentiation, and tissue architecture in the healthy parts of mucosa are noted after exposure to Monensin sodium salt
[2]
.
Information
CAS No
22373-78-0
Formula
C
36
H
61
NaO
11
Clinical Information
clinicalinformation
Pathway
Anti-infection
Target
Bacterial
Specifications
Purity / Grade
>98%
Solubility
DMSO : < 1 mg/mL (insoluble or slightly soluble); H2O : < 0.1 mg/mL (insoluble)
Smiles
smiles
Misc Information
Alternative Names
Monensin A sodium salt
Observed Molecular Weight
692.85
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