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BioChemicals
Tetrandrine
tcsc0007782
Tetrandrine
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AVAILABLE SIZES
100mg
250mg
$
71.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
Tetrandrine (NSC-77037) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated
Ca
2+
current
(ICa) and Ca
2+
-activated
K
+
current
.
IC50 & Target: Ca
2+
current
[1]
K
+
current
[1]
In Vitro:
The effects of Tetrandrine (NSC-77037), a bis-benzyl-isoquinoline alkaloid, on voltage-gated Ca
2+
currents (ICa) and on Ca
2+
-activated K
+
current (IK(Ca)) and channels in isolated nerve terminals of the rat neurohypophysis are investigated using patch-clamp techniques. The non-inactivating component of ICa is inhibited by external Tetrandrine (NSC-77037) in a voltage- and dose-dependent manner, with an IC
50
=10.1μM. Tetrandrine (NSC-77037) decreases the channel-open probability, within bursts, with an IC
50
=0.21 μM
[1]
. To evaluate the effects of Tetrandrine on HCC cells, Huh7, HCCLM9 and Hep3B cells are treated with 0 (DMSO), 0.5, 1, 2 or 4 μM of Tetrandrine for 24 h. The cell proliferation assay indicates that Tetrandrine exhibits almost no effect on the inhibition of HCC cell proliferation at 0.5-2 μM. However, Tetrandrine (NSC-77037) inhibits HCC cell migration in a dose-dependent manner. Furthermore, a wound-healing and transwell assay shows that 2 μM Tetrandrine significantly inhibits HCC cell migration and invasion
[2]
.
In Vivo:
To evaluate the effect of Tetrandrine (NSC-77037) on the inhibition of tumor metastasis in vivo, HCCLM9 subcutaneous tumor xenograft models is established with athymic nude mice. When the tumor volume reach approximately 50 mm
3
, nude mice are orally administered vehicle or Tetrandrine (NSC-77037) (30 mg/kg) every other day for 37 days. Tetrandrine (NSC-77037) treatment inhibits tumor growth by reducing the tumor volume and weight
[2]
.
Information
CAS No
518-34-3
Formula
C
38
H
42
N
2
O
6
Clinical Information
clinicalinformation
Pathway
Membrane Transporter/Ion Channel
Membrane Transporter/Ion Channel
Target
Calcium Channel
Potassium Channel
Specifications
Purity / Grade
>98%
Solubility
DMSO : 5 mg/mL (8.03 mM; Need ultrasonic and warming)
Smiles
smiles
Misc Information
Alternative Names
NSC-77037;d-Tetrandrine
Observed Molecular Weight
622.75
related data
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