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BioChemicals
Diflunisal
tcsc0007468
Diflunisal
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$
119.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (
COX
) Inhibitor.
IC50 & Target: Target: Cyclooxygenase
In Vivo:
Administration of increasing doses of Diflunisal to rats shows that the effect of the dose on the pharmacokinetics of Diflunisal is quite complicated. The plasma concentrations of Diflunisal decline exponentially with time, albeit with a half-life that increases with increasing dose. The CL
P
is reduced considerably when the dose increases from 3 to 10 mg/kg and then remains relatively constant over the dose range of 10 to 60 mg/kg. Diflunisal has been shown to be highly bound to rat plasma protein and dependent on concentration. The fraction of unbound Diflunisal is increased about 10-fold over the concentration range of 5 to 300 μg/mL
[1]
. Diflunisal exhibits activity after oral administration with potency about 25 times greater than that of aspirin, about 3 times that of glafenine and twice that of zomepirac
[2]
.
Information
CAS No
22494-42-4
Formula
C
13
H
8
F
2
O
3
Clinical Information
clinicalinformation
Pathway
Immunology/Inflammation
Target
COX
Specifications
Purity / Grade
>98%
Solubility
DMSO : 50 mg/mL (199.84 mM; Need ultrasonic)
Smiles
smiles
Misc Information
Alternative Names
MK-647
Observed Molecular Weight
250.2
related data
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