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Product Description
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
Information
ApplicationWB, IHC, IF
Species ReactivityHuman, Mouse, Rat
Host SpeciesRabbit
Immunogen / Amino acidsA synthetic peptide of human GEMIN2
ConjugationUnconjugated
ClonalityPolyclonal
IsotypeIgG
Specifications
FormLiquid
Storage BufferPBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage InstructionStore at -20C. Avoid freeze / thaw cycles.
Alternative NamesGEMIN2 antibody Gem-associated protein 2 antibody Gemin-2 antibody Component of gems 2 antibody Survival of motor neuron protein-interacting protein 1 antibody SMN-interacting protein 1 antibody GEMIN2 antibody SIP1 antibody