tcsa6929 Anti GAPDH antibody

GAPDH is a protein encoded by the GAPDH gene which is approximately 36 kDa. GAPDH is localised to the cytoplasm and nucleus. It is involved in glucose metabolism, respiratory electron transport, carbon metabolism and HIF-1 signalling pathway. It is a moonlighting protein based on its ability to perform mechanistically distinct functions. It catalyses an important energy-yielding step in carbohydrate metabolism and also has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions. GAPDH is expressed in the blood, eyes, intestine, kidney and liver. Mutations in the GAPDH gene may result in FMR1-related disorders. STJ96931 was developed from clone 2B8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous GAPDH protein.