tcsa3830 Anti Ki67 antibody

Ki67 is a protein encoded by the MKI67 gene which is approximately 358,6 kDa. Ki67 is localised to the nucleus. It is involved in DNA damage and neuroscience. It is a nuclear protein that is associated with and may be necessary for cellular proliferation. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. It also associates with the surface of the mitotic chromosome, the peri-chromosomal layer, and covers a substantial fraction of the chromosome surface. Ki67 is expressed preferentially during late G1, S, G2 and M phases of the cell cycle. Mutations in the MKI67 gene may result in brain ependymoma and amyloplastic carcinoma. STJ93832 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Ki-67 protein.