Product Description
CTNNB1,also known as β-Catenin,is an evolutionarily conserved,multifunctional intracellular protein. CTNNB1 was originally identified in cell adherens junctions (Ajs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the Ajs,CTNNB1 is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of CTNNB1 activity is associated with multiple diseases including cancers. .
Information
ApplicationWB, IHC
Research AreaCancer, Cardiovascular, Neuroscience, Signal transduction, Stem cells
Species ReactivityHuman, Mouse, Rat
Host SpeciesMouse
Immunogen / Amino acidsRecombinant protein corresponding to Mouse β-catenin
ConjugationUnconjugated
ClonalityMonoclonal
Clones4A3H3
IsotypeIgG
Specifications
FormLiquid
Storage BufferPBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
Concentration420 μg/mL
Recommended DilutionWB 1:500-1:1000
IHC 1:100-1:500
Misc Information
Storage InstructionStore at -20℃. Avoid freeze / thaw cycles.
Alternative NamesBeta catenin,Beta-catenin,Cadherin associated protein,Catenin (cadherin associated protein),beta 1,88kDa,Catenin beta 1,Catenin beta-1,CATNB,CHBCAT,CTNB1,CTNNB,CTNNB1,DKFZp686D02253,FLJ25606,FLJ37923,OTTHUMP00000162082,OTTHUMP00000165222,OTTHUMP00000165223,OTTHUMP00000209288,OTTHUMP00000209289