Product Description
This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13.
Information
ApplicationWB, IHC
Research AreaCancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction
Species ReactivityHuman, Mouse, Rat
Host SpeciesRabbit
Immunogen / Amino acidsRecombinant protein of human SPTLC1
ConjugationUnconjugated
ClonalityPolyclonal
IsotypeIgG
Specifications
FormLiquid
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration1mg/ml
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Misc Information
Storage InstructionStore at -20℃. Avoid freeze / thaw cycles.
Alternative NamesHSAN,HSAN1,HSN1,LBC1,LCB 1,LCB1,Long chain base biosynthesis protein 1,MGC14645,Serine C palmitoyltransferase,Serine palmitoyl CoA transferase 1,Serine palmitoyltransferase 1,Serine palmitoyltransferase long chain base subunit 1,Serine palmitoyltransferase subunit 1,Serine-palmitoyl-CoA transferase 1,SPT 1,SPT1,SPTC1,SPTI,SPTLC 1,SPTLC1